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GLOW — Alphagenics vial
Regenerative · Skin and Beauty

GLOW

GHK-Cu + BPC-157 + TB-500

Combination of research peptides in tissue regeneration and skin

Components3
Total70mg · 90mg
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About GLOW

GLOW combines three peptides studied in different lines of research on tissue repair.

GHK-Cu has been studied for its relationship with collagen synthesis and extracellular matrix remodeling; BPC-157, for its association with angiogenesis and soft-tissue healing; and TB-500, for its relationship with cell migration and wound healing. Two molecules are sold under the name TB-500: the synthetic N-acetylated fragment Ac-LKKTETQ (thymosin β4 sequence 17-23, short chain) and full-length 43-amino-acid thymosin β4 (long chain); the form present in each lot is stated on its certificate of analysis, and each finding states which molecule was studied. No published studies of the three-peptide blend were found; the evidence refers to each component on its own. Each component keeps its own physicochemical data, detailed below.

Quick guide · 5 key points

GLOW: three repair peptides

GLOW combines three peptides studied in different stages of tissue repair: collagen, blood vessels and cell migration. Here are five things the research shows.

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  1. 1

    Three repair mechanisms in one blend

    GHK-Cu has been studied for collagen synthesis; BPC-157, derived from a protein in human gastric juice, for blood vessels and tendons; and TB-500 (short-chain fragment or full-length thymosin β4, depending on the lot), for cell migration and wound closure. The published evidence is for each component on its own, not for the blend.1,3,11

    3Peptides, each with its own line of research
  2. 2

    GHK-Cu: collagen in cells and in rats

    In human fibroblasts, GHK-Cu has been associated with more collagen synthesis at nanomolar concentrations. In wound chambers implanted under the skin of rats, it was associated with a concentration-dependent rise in collagen and glycosaminoglycans; collagen synthesis was stimulated twice as much as that of other proteins.1,2

    2×Collagen stimulation versus other proteins, in rats
  3. 3

    BPC-157: tendons and new blood vessels

    In rat tendon fibroblasts, BPC-157 has been associated with more cell migration and better survival under oxidative stress. In rats with hind-limb ischemia, studies observed faster recovery of blood flow and more vessels, along with activation of the VEGFR2 receptor.3,4

    VEGFR2Vascular growth receptor linked to the effect of BPC-157
  4. 4

    TB-500: two molecules with the same name

    TB-500 can be the short chain, the N-acetylated form of LKKTETQ (thymosin β4 sequence 17-23, with its actin-binding domain), or the long chain, full-length 43-amino-acid thymosin β4. Short chain: in aged mice, the synthetic peptide LKKTETQ (non-acetylated) has been associated with dermal wound repair comparable to that of full-length thymosin β4. Most published data (e.g., +61% re-epithelialization in rats) come from the long chain.11,10,5

    7 aaShort-chain TB-500, versus 43 aa for the long chain
  5. 5

    How strong the evidence is

    A study in 32 rats with a repaired Achilles tendon tested BPC-157 + TB-500 (form not specified): the combination added no benefit over either one alone. Full-length thymosin β4 (long chain, not the fragment) reached phase 2 trials in skin ulcers; for BPC-157, a 2025 review found only three pilot studies in humans. No published study of all three together was found.9,6,7,8

    Phase 2Most advanced stage: full-length thymosin β4, not the fragment
References
  1. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343-6. PMID 3169264
  2. Maquart FX, et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. J Clin Invest. 1993;92(5):2368-76. PMID 8227353
  3. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-80. PMID 21030672
  4. Hsieh MJ, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333. PMID 27847966
  5. Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-8. PMID 10469335
  6. Guarnera G, et al. The effect of thymosin treatment of venous ulcers. Ann N Y Acad Sci. 2010;1194:207-12. PMID 20536470
  7. Treadwell T, et al. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012;1270:37-44. PMID 23050815
  8. McGuire FP, et al. Regeneration or risk? A narrative review of BPC-157 for musculoskeletal healing. Curr Rev Musculoskelet Med. 2025;18(12):611-619. PMID 40789979
  9. Biçer O, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: a histopathological and biomechanical study. Jt Dis Relat Surg. 2026;37(3):822-837. PMID 42542926
  10. Philp D, et al. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003;11(1):19-24. PMID 12581423
  11. Ho EN, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012;1265:57-69. PMID 23084823

Components per vial

Reference amounts of the formulation. The physicochemical data correspond to each individual peptide.

GHK-Cu

50 / 70 mg
GlyHisLys · Cu²⁺
Molecular formula
C14H22CuN6O4
Molecular weight
401.9 g/mol
CAS number
89030-95-5
PubChem CID
71587328
Length
3 aa + Cu

BPC-157

10 mg
G1E2P3P4P5G6K7P8A9D10D11A12G13L14V15
Molecular formula
C62H98N16O22
Molecular weight
1419.5 g/mol
CAS number
137525-51-0
PubChem CID
9941957
Length
15 aa

TB-500 (Ac-LKKTETQ / Tβ4)

10 mg
Length
Depends on the lot (see certificate of analysis): Ac-LKKTETQ fragment, short chain (7 aa; C38H68N10O14; 889.0 g/mol), or full-length thymosin β4, long chain (43 aa; C212H350N56O78S; 4963.4 g/mol)

Five findings from studies

Summary of results reported in the scientific literature. Each finding describes what was observed in the cited study, in its specific population and conditions; it does not constitute a therapeutic indication.

  1. In vitro

    GHK-Cu: in human fibroblasts it has shown increased collagen synthesis at nanomolar concentrations.

    Maquart FX et al. FEBS Lett. 1988;238:343-346 · PMID 3169264
  2. Preclinical

    GHK-Cu: in a rat model of subcutaneously implanted wound chambers it has been associated with a concentration-dependent increase in collagen content in the repair tissue.

    Maquart FX et al. J Clin Invest. 1993;92:2368-2376 · PMID 8227353
  3. In vitro

    BPC-157: in tendon fibroblasts it has shown increased cell migration and survival.

    Chang CH et al. J Appl Physiol. 2011;110:774-780 · PMID 21030672
  4. Preclinical

    BPC-157: in a rat hindlimb ischemia model, faster recovery of blood flow and a greater number of vessels have been observed, associated with VEGFR2 activation.

    Hsieh MJ et al. J Mol Med. 2017;95:323-333 · PMID 27847966
  5. Preclinical

    TB-500 short chain (LKKTETQ fragment): in aged mice, the synthetic heptapeptide LKKTETQ (the sequence of short-chain TB-500, without the N-terminal acetylation), which reproduces the actin-binding domain of thymosin β4, has been associated with dermal wound repair comparable to that of full-length thymosin β4.

    Philp D et al. Wound Repair Regen. 2003;11:19-24 · PMID 12581423

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